As of the census of 2010, there were 32,786 people, 13,080 households, and 8,528 families residing in the town. The population density was 2,132.9 people per square mile (823.7/km2). There were 13,368 housing units at an average density of 886.3 per square mile (342.3/km2). The racial makeup of the town was 87.3% White, 2.6% African American, 0.11% Native American, 7.2% Asian, 0.05% Pacific Islander, 0.77% from other races, and 2% from two or more races. Hispanic or Latino of any race were 3.2% of the population.
There were 13,080 households out of which 30.3% had children under the age of 18 living with them, 54.5% were married couples living together, 8.2% had a female householder with no husband present, and 34.8% were non-families. 28.3% of all households were made up of individuals and 9.8% had someone living alone who was 65 years of age or older. The average household size was 2.42 and the average family size was 3.02.
In the town the population was spread out with 23.0% under the age of 18, 5.1% from 18 to 24, 34.3% from 25 to 44, 23.3% from 45 to 64, and 14.3% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 89.7 males. For every 100 females age 18 and over, there were 85.3 males.
According to a 2007 estimate, the median income for a household in the town was $81,855, and the median income for a family was $105,056. Males had a median income of $51,964 versus $41,060 for females. The per capita income for the town was $36,358. About 1.7% of families and 2.8% of the population were below the poverty line, including 2.4% of those under age 18 and 5.3% of those age 65 or over.
Natick is surrounded, on three sides, by five of the ten most affluent towns in Massachusetts  with Wayland to the north, Weston to the northeast, Wellesley to the east, Dover to the southeast, and Sherborn to the southwest. In addition to these five very-wealthy communities, Framingham lies immediately to the west. Framingham is largely middle class and has areas of semi-rural affluence, although Framingham has the issue of urban blight in its downtown area which Natick has managed to avoid.